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Katherine L B Borden Selected Research

Eukaryotic Initiation Factor-4E

1/2022The search for genetic dark matter and lessons learned from the journey.
10/2020The eukaryotic translation initiation factor eIF4E elevates steady-state m7G capping of coding and noncoding transcripts.
11/2019Structural studies of the eIF4E-VPg complex reveal a direct competition for capped RNA: Implications for translation.
1/2019Biochemical and Structural Insights into the Eukaryotic Translation Initiation Factor eIF4E.
1/2019Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia.
5/2016Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E.
2/2016Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas.
1/2016The eukaryotic translation initiation factor eIF4E wears a "cap" for many occasions.
1/2015A phase I trial of ribavirin and low-dose cytarabine for the treatment of relapsed and refractory acute myeloid leukemia with elevated eIF4E.
1/2015The eukaryotic translation initiation factor eIF4E in the nucleus: taking the road less traveled.
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Katherine L B Borden Research Topics

Disease

36Neoplasms (Cancer)
01/2022 - 12/2003
8Leukemia
10/2020 - 02/2005
8Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
05/2016 - 12/2004
3Glioma (Gliomas)
01/2019 - 07/2014
2Infections
11/2019 - 02/2005
2Melanoma (Melanoma, Malignant)
11/2018 - 06/2013
2Lymphoma (Lymphomas)
02/2016 - 10/2010
2Neoplasm Metastasis (Metastasis)
03/2014 - 05/2011
2Breast Neoplasms (Breast Cancer)
05/2011 - 11/2002
1Genetic Translocation (Chromosomal Translocation)
12/2020
1Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
01/2019
1B-Cell Lymphoma (Lymphoma, B Cell)
02/2016
1B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
05/2015
1Carcinogenesis
07/2013
1Ovarian Neoplasms (Ovarian Cancer)
07/2009
1Virus Diseases (Viral Diseases)
11/2008
1Lassa Fever (Fever, Lassa)
06/2008
1Starvation
04/2008
1Nijmegen Breakage Syndrome
04/2008
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
12/2004
1BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
12/2003

Drug/Important Bio-Agent (IBA)

27Eukaryotic Initiation Factor-4EIBA
01/2022 - 12/2003
14Proteins (Proteins, Gene)FDA Link
12/2021 - 11/2002
13Peptide Initiation Factors (Initiation Factor)IBA
01/2022 - 12/2004
10Ribavirin (Virazole)FDA LinkGeneric
01/2019 - 12/2004
7RNA (Ribonucleic Acid)IBA
01/2022 - 01/2007
7Messenger RNA (mRNA)IBA
12/2020 - 03/2009
4EnzymesIBA
10/2021 - 07/2014
4Pharmaceutical PreparationsIBA
10/2018 - 01/2013
2Cytarabine (Cytosar-U)FDA LinkGeneric
01/2019 - 01/2015
2Mechanistic Target of Rapamycin Complex 1IBA
11/2018 - 06/2013
2Transcription Factors (Transcription Factor)IBA
11/2018 - 07/2014
1Sorafenib (BAY 43-9006)FDA Link
10/2021
1TamoxifenFDA LinkGeneric
10/2021
1Microphthalmia-Associated Transcription FactorIBA
11/2018
1Amino AcidsFDA Link
11/2018
1Biological ProductsIBA
01/2018
1VorinostatFDA Link
05/2015
1Environmental CarcinogensIBA
05/2015
1TransferasesIBA
05/2015
1Uridine Diphosphate (UDP)IBA
05/2015
1Glucuronosyltransferase (UDP Glucuronosyltransferase)IBA
07/2014
1integrin-linked kinaseIBA
03/2014
1IntegrinsIBA
03/2014
1Nuclear Pore Complex Proteins (Nucleoporins)IBA
01/2012
1Phenobarbital (Luminal)FDA Link
05/2011
1Biomarkers (Surrogate Marker)IBA
05/2011
1Peptides (Polypeptides)IBA
07/2009
1Carrier Proteins (Binding Protein)IBA
07/2009
1GonadotropinsIBA
07/2009
15,6-dihydroxy-2-dimethylaminotetralin (M 7)IBA
10/2008
1proto-oncogene protein Spi-1IBA
08/2008
1plasma protein Z (protein Z)IBA
06/2008
1Phosphotransferases (Kinase)IBA
04/2008
1Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
01/2007
1Proline (L-Proline)FDA Link
02/2005
1Promyelocytic Leukemia ProteinIBA
11/2002

Therapy/Procedure

6Therapeutics
01/2019 - 10/2010